Systematic Reviews and Meta-Analysis of Prognosis Research

The number of primary studies evaluating prognostic factors and models is rising per day. Alike for therapies and diagnostic tests, critically summarizing and analyzing the evidence form prognosis studies in a systematic review and meta analysis is beneficial for health care professionals seeking the best evidence.

Dr. J.A.A.G. (Anneke) Damen
Klinisch epidemioloog
  • 3 weeks - 14 hrs / wk
  • Academic Certificate
  • 1.5 EC
  • Online
  • English
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Inschrijving sluit op 28/10/2024 130 dagen tot einde inschrijving
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Course description

Learning objectives

By the end of the course, you’ll should be able to:

  • Explain the rationale for performing a systematic review of prognostic studies
  • List the key steps of a systematic review of prognostic studies
  • Formulate a focused review question addressing a prognostic problem
  • Critically appraise the evidence from primary prognostic studies using the CHARMS instrument
  • Formulate the difficulties of meta-analysis of prognostic research
  • Understand, interpret and undertake systematic review and meta-analysis of prognostic studies


This course includes an exam. The exams are, by default, online using online proctoring. If you wish to take the exam on-site in Utrecht, the Netherlands, this is possible as well.

Exam edition November 2023
The exam will take place on November 24th, 2023 from 14:15 – 16:15 CET. The re-examination will take place on January 12th, 2024 from 14:15 – 16:15 CET. Note: these times might be subject to change. The exact time and place will be announced as soon as possible in the learning environment and any changes announced there will overrule the information here.

The exam is not compulsory. However, if you want to receive the Course Certificate and the credits, it is obligatory to take the exam. You are allowed to redo the exam once.

It might be that, due to a force majeure situation, you cannot be present during the first exam moment.

• MSc Epidemiology Postgraduate students must then, preferably prior to the first exam option, ask the academic counsellor for permission to be absent. Please note that the academic counsellor can ask for some form of proof of your absence (e.g. in case of illness) to establish if you are applicable for authorized absence. Jaco de Fockert-Koefoed, MSc is the academic counsellor you need to turn to through

• All other participants should contact the MSc Epidemiology Office instead, through

In short, as of now, it is no longer possible to skip the first exam option and -automatically- enroll in the second (re-sit) exam. Unauthorized absence during the first exam period results in no longer being able to finish the course that college year.

Requirements & material

To enroll in this course, you need:

• A BSc or MSc degree in biomedical sciences, pharmaceutical sciences, medicine or veterinary medicine, or a comparable degree
• Access to the program R
• We strongly recommend that you take part in our online course Prognostic Research, prior to enrolling in this course
• Sufficient proficiency in English reading and writing

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